In this article, we discuss how collective impact initiatives have effectively transitioned beyond the initial steps of building a steering committee and establishing a common agenda to creating an infrastructure that can discover and execute strategies that lead to positive, sustained change. In collective impact, that infrastructure involves working groups, which use the initiative’s common agenda to further define and execute strategies. We will explain the key considerations when determining which working groups to create, when to launch working groups, how to choose members best positioned for and suited to the tasks at hand, and how working groups can succeed in their first six months.